Human Bone Marrow Stromal Cells

Stromal cells are connective tissue cells of any organ for example in the uterine mucosa endometrium prostate bone marrow lymph node and the ovary they are cells that support the function of the parenchymal cells of that organ.

Human bone marrow stromal cells.

Cd2 t lymphocytes obtained from either the donor of bone marrow stromal cells bmscs or a third party were cultured in mixed lymphocyte reactions mlrs with either allogeneic dendritic cells dcs or peripheral blood lymphocytes pbls. Human bone marrow stromal cells cultured using the mesencult acf culture kit maintain multi lineage differentiation potential. Adult bone marrow also contains stromal stem cells which contribute to the regeneration of several tissues such as bone cartilage muscle ligament tendon adipose tissue and marrow stroma 9 human bmscs have been identified and characterized and it has been shown that they support hematopoietic progenitors and secrete a number of. Sscs have been identified as pericytes cells on the abluminal side of marrow sinusoids and have demonstrated the ability to self renew.

In birds and mammals bone marrow is the primary site of new blood cell production or haematopoiesis. Human bone marrow stromal cells derived in acf medium catalog 70071 using the mesencult acf culture kit catalog 05449 differentiate to a adipocytes oil red o staining b chondrocytes alcian blue and nuclear fast red staining and c. Bone marrow stromal cells bmscs contains a subset of skeletal stem cells sscs that are multipotent capable of forming cartilage bone hematopoiesis supportive stroma and marrow adipocytes. It is composed of hematopoietic cells marrow adipose tissue and supportive stromal cells in adult humans bone marrow is primarily located in the ribs vertebrae sternum and bones of the pelvis.